Journal: Journal of the American Society of Nephrology : JASN
Article Title: Effects of Proximal Tubule Shortening on Protein Excretion in a Lowe Syndrome Model
doi: 10.1681/ASN.2019020125
Figure Lengend Snippet: Model for how shortened PTs may explain kidney pathogenesis in LS. We hypothesize that defective cell division caused by lack of functional OCRL alters PT development or regeneration after injury, resulting in shorter (and/or narrower) PTs. Decreased PT reabsorption area can lead to incomplete reabsorption of LMWPs, and can also account for the aminoaciduria, hypercalciuria, and RTA characteristically observed in patients (see text for details). PTs have a high excess capacity for glucose uptake, so shorter PTs do not necessarily lead to glycosuria.
Article Snippet: Mathematic Modeling of Protein Reabsorption A mathematic model describing protein reabsorption along the human PT was created in MATLAB (MATLAB R2017a with ode45 solver).
Techniques: Functional Assay